The digestion and absorption of CoQ10 in the body involves several processes:
Metabolism:
Over 60% of orally ingested CoQ10 is excreted through urine.
Absorption:
CoQ10 is absorbed in the small intestine, entering the lymphatic system before reaching the bloodstream. Its hydrophobic nature and large molecular size limit its absorption, resulting in poor uptake that varies with food intake and fat content. Absorption rates are lower when taken on an empty stomach, while a high-fat diet enhances absorption.
Distribution:
In preclinical studies involving intravenous administration, tissues with high energy demands or metabolic activity, such as the heart, kidneys, liver, and muscles, tend to show higher levels of CoQ10.
